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max) Dendritic cells (DC) are professional antigen-presenting cells that orchestrate immune responses. The human DC population comprises two main functionally-specialized lineages, whose origins and differentiation pathways remain incompletely defined. Here we combine two high-dimensional technologies, single-cell mRNA sequencing and Cytometry by Time-of-Flight (CyTOF), to identify human blood CD123 + CD33 + CD45RA + DC precursors (pre-DC). Pre-DC share surface markers with plasmacytoid DCdoi:10.1126/science.aag3009 pmid:28473638 fatcat:d7qakxhmzvglblbll2w25xtxaq