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Despite a considerable advance made in epileptology, resistant epilepsies are about 30% among all epilepsy types particularly in patients with focal seizures. In these cases, there is hope for the success of neurosurgical treatment and the synthesis of new antiepileptic drugs (AEDs). The authors provide a review of the literature dealing the new AED perampanel (Fycompa) and consider its mechanism of action, pharmacokinetics, clinical and postmarketing trials of its efficacy, tolerability, anddoi:10.17650/2073-8803-2014-9-3-36-42 doaj:0411fc63e4de42aba66c40b43926af44 fatcat:p2yzyphuezacxjwixnvb5mwuva