USE OF THE NEW ANTIEPILEPTIC DRUG PERAMPANEL (FYCOMPA) IN THE TREATMENT OF EPILEPSY: A REVIEW OF FOREIGN LITERATURE

O. A. Pylaeva, K. Yu. Mukhin
2015 Russkij Žurnal Detskoj Nevrologii  
Despite a considerable advance made in epileptology, resistant epilepsies are about 30% among all epilepsy types particularly in patients with focal seizures. In these cases, there is hope for the success of neurosurgical treatment and the synthesis of new antiepileptic drugs (AEDs). The authors provide a review of the literature dealing the new AED perampanel (Fycompa) and consider its mechanism of action, pharmacokinetics, clinical and postmarketing trials of its efficacy, tolerability, and
more » ... tolerability, and safety. Based on the data available in the literature, it may be concluded that parampanel is a promising highly effective and well tolerated AED to treat partial and secondary generalized seizures.
doi:10.17650/2073-8803-2014-9-3-36-42 doaj:0411fc63e4de42aba66c40b43926af44 fatcat:p2yzyphuezacxjwixnvb5mwuva