Neural Synchrony in Brain Disorders: Relevance for Cognitive Dysfunctions and Pathophysiology

Peter J. Uhlhaas, Wolf Singer
2006 Neuron  
Following the discovery of context-dependent synchronization of oscillatory neuronal responses in the visual system, novel methods of time series analysis have been developed for the examination of task-and performance-related oscillatory activity and its synchronization. Studies employing these advanced techniques revealed that synchronization of oscillatory responses in the b-and g-band is involved in a variety of cognitive functions, such as perceptual grouping, attention-dependent stimulus
more » ... election, routing of signals across distributed cortical networks, sensorymotor integration, working memory, and perceptual awareness. Here, we review evidence that certain brain disorders, such as schizophrenia, epilepsy, autism, Alzheimer's disease, and Parkinson's are associated with abnormal neural synchronization. The data suggest close correlations between abnormalities in neuronal synchronization and cognitive dysfunctions, emphasizing the importance of temporal coordination. Thus, focused search for abnormalities in temporal patterning may be of considerable clinical relevance. Neuron 156 Neuron 158
doi:10.1016/j.neuron.2006.09.020 pmid:17015233 fatcat:av72c6ln3fd4pl5ubz6oaiowby