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We describe the case of a patient with high grade, triple hit, Non-Hodgkin's Lymphoma (NHL) who underwent high-dose chemotherapy and Autologous Stem Cell Transplantation (ASCT) as a consolidation. Patient received BEAM conditioning regimen. She engrafted after usual post ASCT course. However, 2 months post ASCT she developed atypical neurologic symptoms and findings leading to general weakness mainly in the lower extremities with multiple falls, mental status changes and high CSF protein withdoi:10.26420/jblooddisordl.2021.1061 fatcat:ohm72ke4xvgtfdggoyb3efhn4a