Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides

Rosana Ribić, Lidija Habjanec, Branka Vranešić, Ruža Frkanec, Srđanka Tomić
2011 Croatica Chemica Acta  
A novel class of mannosylated adamantyltripeptides, general formula of which is α-Man-OCH 2 CH(CH 3 )CO-AdGly-L-Ala-D-isoGln, were prepared, characterized, and their possible immunomodulatory properties investigated in some preliminary tests in vivo. All newly synthesized glycopeptides comprise in their structure the adamantylglycyl moiety linked to the dipeptide L-Ala-D-isoGln, as well as mannose. Adjuvant activity of mannosylated adamant-2-yl tripeptides was tested in the mouse model using
more » ... ouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM, β-D-GlcNAc-(1→4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(εNH 2 )-D-Ala-D-Ala). (
doi:10.5562/cca1827 fatcat:jps7ydladnbezbzjflgawf2fu4