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Randomized Trial of Time-Limited Interruptions of Protease Inhibitor-Based Antiretroviral Therapy (ART) vs. Continuous Therapy for HIV-1 Infection
2011
PLoS ONE
The clinical outcomes of short interruptions of PI-based ART regimens remains undefined. Methods: A 2-arm non-inferiority trial was conducted on 53 HIV-1 infected South African participants with viral load ,50 copies/ml and CD4 T cell count .450 cells/ml on stavudine (or zidovudine), lamivudine and lopinavir/ritonavir. Subjects were randomized to a) sequential 2, 4 and 8-week ART interruptions or b) continuous ART (cART). Primary analysis was based on the proportion of CD4 count .350
doi:10.1371/journal.pone.0021450
pmid:21738668
pmcid:PMC3125169
fatcat:nizgz7j2xjcnpedeib7hrkxb3y