Snake bite leads to medical emergencies and sometimes death. It is clinically managed by administration of monovalent/polyvalent antisera and it exhibit early or late adverse reactions and sometimes these adverse effects lead to fatalities. snake bite by the traditional healers; however, there is paucity of scientific data this claim. To examine the anti-snake venom activities of ethanolic and aqueous extracts of Cassia hirsute against Indian cobra (Naja naja activities of ethanolic and aqueous

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... extracts of naja) venom induced toxicity was studied in mice, rats and sheep by as follows: Phospholipase A2 induced hemolysis on sheep RBC, anticoagulation[Coagulation activity], Naja naja activity against lethality induced by Naja naja induced odema, liver function of venomized rats. as 2mg/kg and both ACH and ECH shown significant neutralization of induced lethality. Both extracts inhibited phospholipase A RBC's and showed a high significant reductio venom with 80.51% inhibition of anti-coagulation of ECH at 350 µg and 79.84% of ACH at 300 µg. ECH and ACH 300, 600 and 900 mg/kg shows significant ( bleeding time also. These findings suggest a potential antivenom role of against Naja naja venom. Abstract Article Information Snake bite leads to medical emergencies and sometimes death. It is clinically managed by antisera and it exhibit early or late adverse reactions and sometimes these adverse effects lead to fatalities. Cassia hirsute has been used against snake bite by the traditional healers; however, there is paucity of scientific data in support of snake venom activities of ethanolic and aqueous extracts of Naja naja) venom induced toxicity. Anti-snake venom activities of ethanolic and aqueous extracts of Cassia hirsute against Indian cobra (Naja ) venom induced toxicity was studied in mice, rats and sheep by using various models induced hemolysis on sheep RBC, Naja naja induced Naja naja induced bleeding, In-vivo Neutralization Naja naja venom (2mg/kg) in rats, Naja naja venom induced odema, liver function of venomized rats. The Minimum lethal dose (MLD) was found as 2mg/kg and both ACH and ECH shown significant neutralization of Naja naja venom induced lethality. Both extracts inhibited phospholipase A2 dependent hemolysis of sheep RBC's and showed a high significant reduction (P<0.001) in the anti-coagulant activity of coagulation of ECH at 350 µg and 79.84% of ACH at 300 µg. ECH and ACH 300, 600 and 900 mg/kg shows significant (P<0.001) decrease in st a potential antivenom role of Cassia hirsute