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Estimating genetic nurture with summary statistics of multi-generational genome-wide association studies
Marginal effect estimates in genome-wide association studies (GWAS) are mixtures of direct and indirect genetic effects. Existing methods to dissect these effects require family-based, individual-level genetic and phenotypic data with large samples, which is difficult to obtain in practice. Here, we propose a novel statistical framework to estimate direct and indirect genetic effects using summary statistics from GWAS conducted on own and offspring phenotypes. Applied to birth weight, ourdoi:10.1101/2020.10.06.328724 fatcat:gje7cz3jongjhlwwgm6cltphaa