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Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease
Soluble α-synuclein aggregates varying in size, structure, and morphology have been closely linked to neuronal death in Parkinson's disease. However, the heterogeneity of different co-existing aggregate species makes it hard to isolate and study their individual toxic properties. Here, we show a reliable non-perturbative method to separate a heterogeneous mixture of protein aggregates by size. We find that aggregates of wild-type α-synuclein smaller than 200 nm in length, formed during an indoi:10.17863/cam.89836 fatcat:ef3mtcboybfe5hdqeku5pff25i