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Tumors and their microenvironments: tilling the soil. Commentary re: A. M. Scott et al., A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin. Cancer Res., 9: 1639-1647, 2003
2003
Clinical Cancer Research
The conventional concept of tumor-host interactions is rooted in the realm of parasitology. A tumor invades an unsuspecting host, and in response to this assault, the host attempts to resist the advances of the tumor by calling on the armamentarium of the immune system. This implies a fundamental opposition between the tumor and host in purpose and intent. However, an accumulation of evidence points to an alternative paradigm, where the tumor microenvironment is not an idle bystander, but
pmid:12738710
fatcat:fpxlyydmnza7dhmxrfhuupsxc4