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Phenylmethimazole Suppresses dsRNA-Induced Cytotoxicity and Inflammatory Cytokines in Murine Pancreatic Beta Cells and Blocks Viral Acceleration of Type 1 Diabetes in NOD Mice

Kelly McCall, Martin Schmerr, Jean Thuma, Calvin James, Maria Courreges, Fabian Benencia, Ramiro Malgor, Frank Schwartz
2013 Molecules  

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Accumulating evidence supports a role for viruses in the pathogenesis of type 1 diabetes mellitus (T1DM). Activation of dsRNA-sensing pathways by viral dsRNA induces the production of inflammatory cytokines and chemokines that trigger beta cell apoptosis, insulitis, and autoimmune-mediated beta cell destruction. This study was designed to evaluate and describe potential protective effects of phenylmethimazole (C10), a small molecule which blocks dsRNA-mediated signaling, on preventing dsRNA
more » ... vation of beta cell apoptosis and the inflammatory pathways important in the pathogenesis of T1DM. We first investigated the biological effects of C10, on dsRNA-treated pancreatic beta cells in culture. Cell viability assays, quantitative real-time PCR, and ELISAs were utilized to OPEN ACCESS
doi:10.3390/molecules18043841 pmid:23535518 fatcat:ihjppygmurf7hgst3klidbnuve
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Kelly McCall, Martin Schmerr, Jean Thuma, Calvin James, Maria Courreges, Fabian Benencia, Ramiro Malgor, Frank Schwartz. "Phenylmethimazole Suppresses dsRNA-Induced Cytotoxicity and Inflammatory Cytokines in Murine Pancreatic Beta Cells and Blocks Viral Acceleration of Type 1 Diabetes in NOD Mice." Molecules 18.4 (2013) 3841-3858