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The neurophysiological mechanism for increasing strength by resistance training has not been understood precisely. The purpose of this study was to examine the effect of 8 weeks resistance training (RT) on A 12 acetylcholinesterase (AChE) activity in rat muscle. Materials and Methods: In this experimental study, 16 male rats were randomly assigned into two groups: resistance training and control. The 8 weeks (5 sessions/week) resistance training consisted of climbing (3 sets of 4 repeats with afatcat:ybx5iqvgdjantpewoirrmr6dfe