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Single Oral Dose of Geranylgeranylacetone Induces Heat-Shock Protein 72 and Renders Protection Against Ischemia/Reperfusion Injury in Rat Heart
Background-Induction of heat-shock proteins (HSPs) results in cardioprotection against ischemic insult. Geranylgeranylacetone (GGA), known as an antiulcer agent, reportedly induces HSP72 in the gastric mucosa and small intestine of rats. The present study tested the hypothesis that oral GGA would induce HSP72 in the heart and thus render cardioprotection against ischemia/reperfusion injury in rats. Methods and Results-Cardiac expression of HSPs was quantitatively evaluated in rats by Westerndoi:10.1161/hc3901.095771 pmid:11591623 fatcat:5d5gger67vhtrgdj47odsiunh4