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STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth
2017
Cell Reports
Graphical Abstract Highlights d STAT3 is essential for resting lymphocytes to initiate growth and proliferation d The metabolic effect of STAT3 is dependent on transcriptional regulation of CS d Without STAT3, lipid synthesis, growth, and proliferation are blocked d Growth and proliferation can be rescued by providing exogenous citrate SUMMARY Citrate is a required carbon precursor for de novo fatty acid and membrane lipid synthesis. However, the pathways regulating intracellular citrate,
doi:10.1016/j.celrep.2017.04.012
pmid:28467904
fatcat:ze6vboepirdc5hqfqaax5cq7re