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Deciphering protein network organization using phylogenetic profile groups
2005
Genome Informatics Series
Phylogenetic profiling is now an effective computational method to detect functional associations between proteins. The method links two proteins in accordance with the similarity of their phyletic distributions across a set of genomes. While pair-wise linkage is useful, it misses correlations in higher order groups: triplets, quadruplets, and so on. Here we assess the probability of observing co-occurrence patterns of 3 binary profiles by chance and show that this probability is asymptotically
pmid:16362916
fatcat:xud7pvdjvneu3je33wfysuovau