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Creation of a Genetic Calcium Channel Blocker by Targeted Gem Gene Transfer in the Heart
2004
Circulation Research
Calcium channel blockers are among the most commonly used therapeutic drugs. Nevertheless, the utility of calcium channel blockers for heart disease is limited because of the potent vasodilatory effect that causes hypotension, and other side effects attributable to blockade of noncardiac channels. Therefore, focal calcium channel blockade by gene transfer is highly desirable. With a view to creating a focally applicable genetic calcium channel blocker, we overexpressed the ras-related small
doi:10.1161/01.res.0000138449.85324.c5
pmid:15242970
fatcat:kb6ihcrajzculj2ghjotz4uy3a