Cardiovascular risk factors contribute to the variance of wall-to-lumen ratio
method of BP measurement was more strongly associated with LVM in a young healthy normotensive population. Methods: Forty-one adults (23AE4yrs, 27% male) took part in the study. LVM was measured using 2-D echocardiography (Vividq, GE) and indexed to body surface area (LVMi). Both office and 24-hour pSBP and cSBP were measured using the Mobil-O-Graph system (IEM, Germany). cSBP's were calculated using brachial mean and diastolic pressures (MAP-cal). Results: Participants had normal office pSBP
... ormal office pSBP (117 AE10 mmHg) and LVMi (79 AE17 g/m 2 ) values. On average, office cSBP (128 AE19 mmHg) was significantly higher than 24cSBP (123 AE14 mmHg, P<0.05). LVMi was not associated with pSBP (rZ0.275, PZ0.82) and weakly associated with 24pSBP (rZ0.320, PZ0.041). However the strongest associations with LVMi were with cSBP MAP-cal (rZ0.506, PZ0.001) and 24cSBP MAP-cal (rZ0.556, P<0.0001). Conclusion: In the current young normotensive population, both office cSBP and 24cSBP were more closely associated with LVMi than peripheral measures of SBP. These findings may have implications for the progression and potential treatment of hypertension-induced target organ damage. Background: Common carotid artery intima-media thickness (cIMT) is an accepted ultrasound marker of subclinical atherosclerosis. It is argued that increase in cIMT may also reflect nonatherosclerotic thickening, thus, lumen diameter could be taken into account. A common approach to account for lumen diameter is wall-to-lumen ratio (WLR), however, its precise relations Background: Hypertensive crisis is an extreme phenotype of increased blood pressure that can lead to organs failure and thrombotic complications. Recently, we were able to show an angiotensin II driven FXI-thrombin amplification loop leading to vascular injury in experimental hypertension.