Feasibility of using double-echo chemical shift imaging to monitor bone mass change in aged patients with lumbago: a pilot study
For aged patients with lumbago, monitoring bone mass change is of great importance for the early diagnosis of osteoporosis.The present study aimed to evaluate the feasibility of using the double-echo chemical shift imaging (CSI) to detect bone mass change in aged population with lumbago. We calculated chemical shift rate (CSR) from double-echo CSI data, and investigated whether CSR correlate to bone mass change. Methods: Two-hundred patients (aged from 60 to 70) with lumbago were included in
... were included in the study. Each subject accepted a lumbar MR examination, for which the ordinary spin echo T1-Weigthed sequence was modified to the double-echo imaging. By doing so, in-phase and out-phase images could be obtained simultaneously with one acquisition. The bone mineral density (BMD) was measured with digital X-ray radiogrammetry (DXR) at the non-dominant hand. Then all subjects were grouped according to their T-value (normal bone mass group, T-value > -1.0; abnormal bone mass group T-value ≤ -1.0). The CSR were calculated based on the signal intensity (SI) measured respectively at the 3 rd -5 th lumbar vertebrae. The association of CSR with BMD was investigated, as well as the impact of other factors on BMD. Results: Patients with normal and abnormal bone mass showed significant difference in CSR (P = 0.008), that positively correlated with T-value (r = 0.281, P 0.001) and negatively correlated with the diagnosis of abnormal bone mass (B = -3.02, P = 0.010). Furthermore, the risk of abnormal bone mass increased by 4.9% for each unit decrease in CSR. Additionally, females were more likely to have abnormal bone mass than males (P = 0.017), while the patients who had type 2 diabetes was determined to undergo 3.25-time risk to have abnormal bone mass, compared to those who did not have. Conclusions: CSR could be used to predict the bone mass loss in elderly patients with lumbago. Our study provides a more economical solution to monitor bone mass lose in elderly patients who complained lumbago and required lumbar MR imaging. And among such patients, the double-echo CSI is highly recommended to those who have type 2 diabetes.