INTERNATIONAL JOURNAL OF PHARMACEUTICAL, CHEMICAL AND BIOLOGICAL SCIENCES EVALUATION OF NOOTROPIC ACTIVITY OF AEGLE MARMELOS EXTRACT USING DIFFERENT EXPERIMENTAL MODELS IN RATS
In the present study A. marmelos selected for evaluation of its anti-amnesic activity and also to study its influence on cholinergic system of the brain of rats, because there were no reporters on its anti-amnesic activity being evaluated pharmacologically. The electroshock (MES) induced amnesia model and scopolamine a well known anticholinergic drug was another model also used to produce loss of memory. Chronic exposure to MES for 7 days produced a significant decrease in latency to expose to
... tency to expose to electroshock grid in step down latency and increased the time of transfer latency in elevated plus maze. The same effect was also seen in scopolamine exposed animals, we found that there was a significant increase in acetylcholinesterase enzyme activity in MES exposed and also in Scopolamine exposed rats. Whereas, administration of ethanol extracts of leaf of A. marmelos simultaneously with MES and scopolamine exposure for 7 days prevented the impairment of memory consolidation and also reduced the Acetyl cholinesterase enzyme activity in all parts of the brain. Daily administration of extracts significantly attenuated the amnesic effect of both MES and scopolamine, which was also observed in performance of learned tasks in elevated plus maze and step-down apparatus.