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Estrogen-triggered delays in mammary gland gene expression during the estrous cycle: evidence for a novel timing system
2006
Journal of Endocrinology
During the estrous cycle and beginning in estrus, the mammary gland undergoes pregnancy-like development that depends on transcriptional regulation by the estrogen and progesterone receptors (ER, PR) and Pax-2 as well as the action of the growth factors Wnt-4 and RANKL. In this report, we first describe the decay and delayed expression of ERa, PR, and Pax-2 proteins as well as depression of Wnt-4 and RANKL mRNA coincident with the strong estrogen surge in proestrus. In time-course studies using
doi:10.1677/joe.1.06725
pmid:16899557
fatcat:3xcfelg2cnatjdnkcoohckd764