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Objective: To report the rare development of manic symptoms in a patient with schizophrenia and discuss its differential diagnosis.Case description: Diagnostic criteria were based on the International Classification of Diseases, 10th edition (ICD-10). A 63-year-old female (diagnosed with schizophrenia since she was 28) was brought to the emergency room with symptoms consistent with manic episode and physical examination suggestive of thyrotoxicosis. Graves' disease was confirmed by subsequentdoi:10.1590/2237-6089-2014-0053 pmid:26222302 fatcat:k2xxzoh4cndbxjpk5f3zze3ltu