CNS volume 10 issue 8 Cover and Back matter

2005 CNS Spectrums  
Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo. Analyses of seventeen placebo controlled trials (modal duration of 10 weeks) in these patients revealed a risk of death in the drug-treated patients of between 1.6 to 1.7 times that seen in placebo-treated patients. Over the course of a typical 10 week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of
more » ... out 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. RISPERDAL'(risperidone) is not approved for the treatment of patients with Dementia-Related Psychosis.
doi:10.1017/s1092852900019519 fatcat:pslmo3yasvdfnntfopkjxoqspu