Feasibility of measurement of bone turnover markers in female patients with systemic lupus erythematosus

Jaroslaw Bogaczewicz, Elzbieta Karczmarewicz, Pawel Pludowski, Jakub Zabek, Jan Kowalski, Jacek Lukaszkiewicz, Anna Wozniacka
2015 Revista Brasileira de Reumatologia (English Edition)  
r e v b r a s r e u m a t o l . 2 0 1 5;5 5(2):133-139 w w w . r e u m a t o l o g i a . c o m . b r Bone turnover Systemic lupus erythematosus Procollagen Osteocalcin Vitamin D a b s t r a c t Objective: To investigate the feasibility of bone turnover markers for the assessment of bone metabolism in patients with systemic lupus erythematosus, according to the guidelines of the International Osteoporosis Foundation and the International Federation of Clinical Chemistry and Laboratory Medicine.
more » ... boratory Medicine. Methods: The study included 43 female systemic lupus erythematosus patients. Serum procollagen type I N propeptide, C-terminal telopeptide of type I collagen, osteocalcin, parathyroid hormone, 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, anti-cardiolipin, anti-dsDNA, and anti-nucleosome levels were measured. Results: Procollagen type I N propeptide and C-terminal telopeptide of type I collagen levels were elevated in systemic lupus erythematosus patients aged >45 in comparison to those aged <45, although with borderline significance (p = 0.05, respectively). Correlations were found between bone turnover markers: the strongest being between procollagen type I N propeptide and osteocalcin ( = 0.69, p < 0.05). Procollagen type I N propeptide and osteocalcin were found to be associated with parathyroid hormone ( = 0.3, = 0.29, respectively, p < 0.05). Age correlated with procollagen type I N propeptide ( = 0.23, p < 0.05). Elevated procollagen type I N propeptide was found more frequently than elevated osteocalcin or C-terminal telopeptide of type I collagen, both in patients aged <45 (p = 0.001) and >45 (p < 0.001). No significant difference in procollagen type I N propeptide, osteocalcin or C-terminal telopeptide of type I collagen levels was found with respect to season, neither in the entire systemic lupus erythematosus group nor in the under-45 or over-45 groups. Previous glucocorticoid treatment was not associated with difference in bone turnover markers. remodelação óssea relacionado com a idade. Pode-se esperar que o PINP aumentado seja o desfecho mais comumente encontrado entre os MRO. É necessário incluir melhores diagnósticos de distúrbios ósseos com MRO, feitos de acordo com as normas internacionais de referência, na abordagem de pacientes com LES, além de avaliar a densidade mineral óssea.
doi:10.1016/j.rbre.2014.10.004 fatcat:mdocgj4l5vcoxbomh4bxbsgyve