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Induction of amino acid transport system A in rat hepatocytes is blocked by tunicamycin
1983
Journal of Biological Chemistry
Primary cultures of rat hepatocytes respond to hormones or amino acid deprivation by increasing System A-mediated neutral amino acid transport. Previous reports have shown this stimulation to be dependent on RNA and protein synthesis, whereas the present report describes the inhibition of System A by tunicamycin (TM), an inhibitor of asparagine-linked glycoprotein biosynthesis. The basal System A activity, as monitored by Na+-dependent 2-aminoisobutyric acid uptake, was decreased by TM when
pmid:6352704
fatcat:kkw3vvzujbhwta5tpdi3tngkjm