Prevalence of HLA DQB1*0602 allele in patients with migraine

Fernando Morgadinho Santos Coelho, Márcia Pradella-Hallinan, Paulo Corrêa Abud, Mario Predazzoli Neto, Fabio Moreira, Lia Rita Azeredo Bittencourt, Mario Fernandes Pietro Peres, Sérgio Tufik
2007 Arquivos de Neuro-Psiquiatria  
BACKGROUND: Studies have shown a high prevalence of migraine among narcoleptic patients. HLA-DQB1*0602 and HLA DRB1 alleles are closely associated with narcolepsy. An increase in the HLA-DRB1 allele frequency in patients with visual aura has raised greater awareness of the genetic background in migraine. PURPOSE: Since the regions DR and DQ of the HLA are in tightly linkage desiquilibrium we hypothesize that HLA-DQB1*0602 might be associated to the pathophysiology of migraine. METHOD: We
more » ... . METHOD: We analyzed the presence of HLA DQB1*0602 allele in 50 healthy subjects with no history of migraine, 53 patients with migraine without aura and 52 patients with migraine with aura. RESULTS: There was no difference in the frequency of HLA DQB1*0602 allele when control subjects and all patients were compared. We failed to note any difference in frequencies when comparing migraine patients with and without aura. CONCLUSION: Further studies with different patient populations, with other hypothalamic markers (melatonin, hypocretin) in migraine patients may shed light on to its pathophysiology.
doi:10.1590/s0004-282x2007000700005 pmid:18345414 fatcat:wgqmn726bjg2ln35bulwgcxe2a