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Angiotensin II (Ang II) type 1 receptors (AT1R) have been proposed to transduce myogenic vasoconstriction to keep blood flow constant in response to intravascular pressure increases. However, the AT1R subtype(s) involved and their downstream signaling pathways are still elusive. We used Agtr1a-/-, Agtr1b-/- and smooth muscle-specific (SM) AT1aR knockout mice, selective Gq/11 protein inhibitors, β-arrestin and Gq/11 signaling biased agonists to characterize the function of AT1Rs in thedoi:10.1101/2020.09.09.289280 fatcat:lww2pzczanaitgkoq5jfaprdca