Granulysin‐Dependent Killing of Intracellular and ExtracellularMycobacterium tuberculosisby Vγ9/Vδ2 T Lymphocytes

Francesco Dieli, Marita Troye‐Blomberg, Juraj Ivanyi, Jean Jacques Fournié, Alan M. Krensky, Marc Bonneville, Marie Alix Peyrat, Nadia Caccamo, Guido Sireci, Alfredo Salerno
2001 Journal of Infectious Diseases  
Contribution of Vg9/Vd2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that Vg9/Vd2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that Vg9/Vd2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in Vg9/Vd2 T lymphocytes,
more » ... y a major role, which indicates that Vg9/Vd2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection.
doi:10.1086/323600 pmid:11574927 fatcat:rx6afiswtbf7zhnuw6mh6elnxy