STUDIES OF ANTI INFLAMMATORY, ANTIPYRETIC AND ANALGESIC EFFECTS OF AQUEOUS EXTRACT OF TRADITIONAL HERBAL DRUG ON RODENTS

Mradu Gupta, Dalia Banerjee, Arup Mukherjee
2013 International Research Journal of Pharmacy  
Aqueous extract of combination of stems of Tinospora cordifolia, fruits of Emblica officinalis and rhizomes of Cyperus rotundus has been used as traditional herbal drug in Indian medicine system for treatment of fever, body ache, joint pain and inflammation. The collected botanicals were subject to physiochemical, pharmacognostical & phytochemical screening before animal experiments. After acute toxicity studies, anti-inflammatory effect was assessed using carrageen induced paw oedema test and
more » ... ntipyretic effect using yeast induced pyrexia method. Tail immersion, hot plate and writhings test were used for determining the analgesic properties. Phytochemical analysis revealed the presence of polyphenolic flavonoids, tannin and saponins. Significant anti-inflammatory, antipyretic and analgesic properties were noticed in dose dependant manner after aqueous extract administration especially at 600 mg/kg dose. These test drug activities were sustained and comparable to the standard drugs while exhibiting no acute toxicity. Aqueous extract of test drug possesses significantly high antiinflammatory, antipyretic and analgesic properties without any acute toxicity possibly due to presence of flavonoids.
doi:10.7897/2230-8407.04321 fatcat:7z4n3rp3abfxnexesfa5g6v25i