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Saturation multipoint linkage mapping of chromosome 6q in type 1 diabetes
Human Molecular Genetics
Linkage analysis of type 1 diabetes sib pair families (n = 334) has suggested two separate regions of human chromosome 6q are linked to disease (designated IDDM5 and IDDM8). To test if these are false positive results, all available sib pair families (n = 429) were typed using a 92% informative map of chromosome 6q and multipoint analysis. The two regions still showed positive evidence of linkage, most notably the proterminal region, 6q27, corresponding to IDDM8 (MLS = 2.57, p = 0.0006; λ s =doi:10.1093/hmg/5.7.1071 pmid:8817350 fatcat:foddffmfzjawbfpa4qtkovcwcy