Effects of exercise training on sexual function in male with heart failure
S. W. Sties, A. I. G. Gonzales, T. M. Marques, A. Z. U. Ulbrich, V. G. A. Angarten, A. S. Schmitt, D. C. B. Bundchen, L. S. M. De Mara, J. V. Valente, T. C. De Carvalho
2013
European Heart Journal
graphy including tissue Doppler (E/e'), cardiopulmonary exercise testing including peak oxygen uptake (pVO2), 6-minute walk test (6MWT), Short Form-36 Health Survey (SF-36) for physical quality of life, Patient Health Questionnaire (PHQ) and Hospital Anxiety and Depression Scale (HADS) for depressive symptoms and/or anxiety. Statistical analyses: multiple linear regression analyses (dependent variables: improvement in physiological/psychological parameters among intervention patients,
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... t variables: age and sex, adjustments: corresponding baseline levels of dependent variables); bivariate analyses using t-tests. Results: Improvements in all examined parameters (E/e', LAVI, pVO2, 6MWT, SF-36, PHQ, HADS) did not differ between age groups split at the median of 67 years in t-tests and they were independent of age on a continuous scale in regression analyses. Greater improvement was found in pVO2 (p=.008) and 6MWT (p=.043) in men versus women. The observed sex difference persisted for both pVO2 (p=.001) and 6MWT (p=.007) after adjustment for corresponding baseline values. Improvement in all other parameters did not differ between the sexes. Only a trend toward greater improvement was detected for SF-36, PHQ and HADS in women versus men. Conclusions: Age did not alter benefits from the EI in functional capacity, diastolic dysfunction, physical quality of life and psychological well-being in patients with DHF. These data clearly demonstrate that elderly DHF patients can benefit from exercise as much as younger patients do. Benefits in maximal and submaximal functional capacity were more pronounced in men versus women. This effect was independent of different baseline levels. All other parameters improved equally well in both sexes. Future research should clarify the observed sex differences and investigate if specific exercise interventions for female patients with DHF are needed. Purpose: Erectile dysfunction is an increasingly common problem in the middleaged world population and has been associated with chronic heart failure (CHF), either as an epiphenomenon or even as an early marker for underlying cardiovascular disease. Exercises interventions have been shown to improve overall cardiovascular health and sexual responses. We aimed to determine whether aerobic exercise training can improve sexual function in male patients with CHF. Methods: We prospectively studied 20 male patients (53.25±8.87 years) with stable CHF, NYHA functional class II and III. Patients underwent supervised treadmill exercise training between the anaerobic threshold and respiratory compensation point, three times a week, 40 minutes each session, for 12 weeks. Medications were not changed during the study. On study entry and at 12 weeks all patients underwent a symptom-limited cardiopulmonary exercise testing, sixminute walk test, and sexual function by International Index of Erectile Function (IIEF). Results expressed as mean and standard deviation, the Wilcoxon test was used to evaluate differences between paired scores and Spearman test to study the correlation between functional capacity and sexual function. Results: At 12 weeks, peak oxygen uptake (VO2peak) increased by 10% (p=0.002), six-minute walk test by 28.1% (p<0.001). The findings were likewise significantly in erectile function (p=0.020), intercourse satisfaction (p=0.006), orgasmic function (p=0.007), overall satisfaction (p=0.017) and sexual desire (p=0.023). Six-minute walk test and VO2peak were only correlated with orgasmic function domain (rho=0.542, p= 0.014; rho= 0.453, p = 0.045, respectively). Conclusions: In stable CHF, treadmill exercise training significantly improves VO2 peak, distance in six-minute walk test and sexual function. Background: It is considered that increased insulin resistance is closely correlated with the exercise capacity in patients with hypertension (HT) and/or dyslipidemia (DL), because it is known to impair the energy metabolism in skeletal muscles. The aim of this study was to investigate the influence of insulin resistance on the exercise capacity in patients with HT and/or DL. Methods: We recruited 45 patients with HT and/or DL and assessed their homeostasis model assessment ratio (HOMA-R)as a parameter of insulin resistance. Patients were defined to have insulin resistance, if their HOMA-R showed >2.50. Patients were divided into low and high HOMA-R groups based on 2.50 of HOMA-R. Oxygen uptake (VO2) at anaerobic threshold (VO2 AT) and peak VO2 were measured by cardiopulmonary exercise testing (CPX) using a treadmill. The exercise capacity was assessed using ratios of measured VO2 to predicted VO2 AT
doi:10.1093/eurheartj/eht310.p5817
fatcat:u24oqvznp5a6djvnhy2cdpwkry