Comparative study of the effects of pyruvate and CG-120 in preventing experimental oxalate urolithiasis in rats

Y Ogawa, K Yamaguchi, T Tanaka, M Morozumi
1986 Hinyokika kiyo. Acta urologica Japonica  
Male Wistar-strain rats which had been fed a calcium-oxalate lithogenic diet (a glycolate diet) developed urinary calculi in 4 weeks. Sodium pyruvate or CG-120 (a mixture of citrate salts) had been added to this diet to determine its effect in preventing lithogenicity. Rats in the group fed a pyruvate diet had, however, almost no stones in the urinary system. Rats in the CG-120 group showed results somewhat similar to those in the pyruvate group. Increased urinary citrate excretion was observed
more » ... in both groups and could be implicated as the main inhibitory factor in stone formation. Therefore, it can be concluded that CG-120 exerts a beneficial effect close to that of pyruvate in preventing calculi formation and that both substances cause a high citrate excretion in urine.
pmid:3812152 fatcat:hkz6otrgsfejhbd3xcwvtd4nsy