Quality of Life in Rheumatoid Arthritis patients taking combination DMARDs

Paramjeet Singh
2017 Journal of Medical Science And clinical Research  
Objective: To assess the QOL of RA patients taking non biological combination DMARDs Material & Methods Study Design: Open Label Study Treatment naïve or chronic cases of RA in age group of 18-60 years of both sex with RA duration >= 6 months and Disease Activity Score (DAS28) >3.2 were included. 131 patients were taken and categorized in 2 study groups for taking of combination of DMARDs. Group-1 patients (n=68) were taking/given. Methotrexate weekly with hydroxychloroquine oral daily. were
more » ... ing/given Methotrexate weekly as in group-1 patients with tablet salfasalazine oral daily. The patients who were already on these combination DMARDs were also included. Observations: The mean duration of disease was 4 years in both the groups. On comparing the baseline and end study values, there was significant improvement in all the domains of domains of WHO-QOL BREFT within the groups. There was significant improvement in quality of life in all the domains of WHOQOL BREF within the groups. However, when comparing domain score between treatment groups, both before and after the treatment, the difference is statistically not significant, except in environmental domain score at the end of the study. Also, within the group, the mean scores of various domains of QOL is significantly increasing at the end of th 5 th follow up with insignificant differences seen for social domain in group-1 only.
doi:10.18535/jmscr/v5i4.193 fatcat:dv72shakyrgsrppksuerjtlssi