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Reactions of Methotrexate with Hypobromous Acid and Hypochlorous Acid
2019
Chemical and pharmaceutical bulletin
Methotrexate is a folate antagonist cytotoxic drug employed in the therapy of cancers and rheumatoid arthritis. Hypobromous acid (HOBr) and hypochlorous acid (HOCl) are generated by eosinophils and neutrophils at inflammation sites. The administered methotrexate may encounter HOBr and HOCl, and react with them to generate products. When methotrexate was incubated with HOBr or HOCl at pH 7.4 and 37°C for 30 min, a single product was generated almost exclusively in each case, identified as
doi:10.1248/cpb.c19-00602
pmid:31685753
fatcat:awjotevpezhurj3qsvx7dppbau