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The LIM-only Proteins FHL2 and FHL3 Interact with α- and β-Subunits of the Muscle α7β1Integrin Receptor
2004
Journal of Biological Chemistry
FHL1, FHL2, and FHL3 are members of the four and one-half LIM domain protein subclass that are expressed in striated muscles. Here we show that FHL2 and FHL3 are novel ␣ 7  1 integrin-interacting proteins. They bind both the ␣and the -subunit as well as different splice isoforms. The minimal binding sites for FHL2 and FHL3 on  1A -chain overlap, whereas on ␣ 7A and ␣ 7B subunits they are situated adjacent. Determining the binding sites for integrins on FHL2 or FHL3 revealed that the
doi:10.1074/jbc.m312894200
pmid:15117962
fatcat:keuz2mrfffbj3hxo2tlmr3cfe4