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Mouse models of central nervous system ageing
Drug Discovery Today : Disease Models
Ageing is accompanied by decreased overall fitness and performance. Studying brain ageing in humans is challenging due to limited or no access to healthy tissue, limited opportunities for interventions and complicated confounding factors. The generation of mouse ageing models with uniform genetic backgrounds significantly contributed to understanding (brain) ageing at the molecular level. Research has focused on evolutionarily conserved mechanisms or pathways that control ageing to facilitatedoi:10.1016/j.ddmod.2018.10.002 fatcat:ngdhpaekoff3pmm5ec5rv7hvra