Copper-Catalyzed Selectivity-Switchable Dehydration/Beckmann Rearrangement Reactions of Aldoxime

Xin Fan, Rong Yi, Fang Wang, Xu Zhang, Qing Xu, Lei Yu
2018 Youji huaxue  
It was found that, copper as a cheap metal, could well catalyze the dehydration reaction of aldoximes to organonitriles in nitrile solvent by using MnO 2 as the co-catalyst and PPh 3 as the ligand. In contrast, instead of organonitriles, the Cu-catalyzed reactions of the aldoximes in water led to amides, which were the products of the Beckmann rearrangements. These interesting selectivity-switchable reactions afford easy accesses to the related useful organic compounds and may be of both
more » ... y be of both academic and practical values.
doi:10.6023/cjoc201805044 fatcat:nw2ldcrokraavcllw2ngqdocfi