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Regulation of the Matrix Microenvironment for Stem Cell Engineering and Regenerative Medicine
2011
Annals of Biomedical Engineering
The extracellular matrix (ECM) microenvironment consists of structural and functional molecules. The ECM relays both biochemical and biophysical cues to and from the cells to modulate cell behavior and function. The biophysical cues can be engineered and applied to cells by means of spatial patterning, matrix rigidity and matrix actuation. Tissue engineering strategies that utilize ECMs to direct stem cell organization and lineage specification show tremendous potential. This review describes
doi:10.1007/s10439-011-0297-2
pmid:21424849
pmcid:PMC3568678
fatcat:bxoxvd7snnfk3mzytg55jdqeve