Evaluation of microfluidic channels with optical coherence tomography

J. Czajkowski, T. Prykäri, E. Alarousu, J. Lauri, R. Myllylä, Matti Kinnunen, Risto Myllylä
2010 Laser Applications in Life Sciences  
Application of time domain, ultra high resolution optical coherence tomography (UHR-OCT) in evaluation of microfluidic channels is demonstrated. Presented study was done using experimental UHR-OCT device based on a Kerr-lens mode locked Ti:sapphire femtosecond laser, a photonic crystal fibre and modified, free-space Michelson interferometer. To show potential of the technique, microfluidic chip fabricated by VTT Center for Printed Intelligence (Oulu, Finland) was measured. Ability for full
more » ... etric reconstruction in non-contact manner enabled complete characterization of closed entity of a microfluidic channel without contamination and harm for the sample. Measurement, occurring problems, and methods of postprocessing for raw data are described. Results present completely resolved physical structure of the channel, its spatial dimensions, draft angles and evaluation of lamination quality. Downloaded From: http://proceedings.spiedigitallibrary.org/ on 05/25/2015 Terms of Use: http://spiedl.org/terms Proc. of SPIE Vol. 7376 737617-6 Downloaded From: http://proceedings.spiedigitallibrary.org/ on 05/25/2015 Terms of Use: http://spiedl.org/terms
doi:10.1117/12.871445 fatcat:ypnkcptaebedzjp5weyofmy3a4