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Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition
2008
Genes and Immunity
We previously identified a novel transcript, mouse (m)IL-20R1a, generated by alternative splicing of the mIL-20R1 gene and studied its possible in vitro functions. However, the function of mIL-20R1a in vivo is unknown. Overexpression of mIL-20R1a in transgenic FvB/N mice resulted in the pathological change of excess calcium deposited in the kidneys. The interplay between renal epithelial cells and calcium oxalate (CaOx) was important in the crystallization involved in the formation of renal
doi:10.1038/gene.2008.93
pmid:19078987
fatcat:qr7lkngr6rbl7pd7xumnothbqe