Effects of Methyl tertiary-Butyl Ether on Hepatic Lipid Peroxidation in Mice
マウスにおけるメチルt‐ブチルエーテルの肝脂質過酸化反応への影響

Takahiko KATOH, Keiichi ARASHIDANI, Makoto KIKUCHI, Masahiro YOSHIKAWA, Yasushi KODAMA
1993 Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)  
The effect of one-shot or repeated treatment with methyl tertiary-butyl ether (MTBE) on lipid peroxidation and cytochrome P-450 in mouse liver was examined. One-shot treatment at the 500mg/kg dose level caused a transient decrease in leukocyte number after 24h. An increased level of lipid peroxide was observed in the liver homogenates 24h after one-shot treatment and four weeks of repeated 200mg/kg treatment. The hepatic cytochrome P-450 content increased after one and four weeks of repeated
more » ... atment (50, 200mg/kg). On the other hand, the treatment did not affect glutathione content and glutathione-S-transferase activity. These results indicate that MTBE treatment caused lipid peroxidation in the liver homogenate and induction of hepatic microsomal cytochrome P-450 content.
doi:10.1265/jjh.48.873 fatcat:fler3nuy5jdvhdfmcbfegorr2y