Neural activation during anticipated peer evaluation and laboratory meal intake in overweight girls with and without loss of control eating

Johanna M. Jarcho, Marian Tanofsky-Kraff, Eric E. Nelson, Scott G. Engel, Anna Vannucci, Sara E. Field, Adrienne L. Romer, Louise Hannallah, Sheila M. Brady, Andrew P. Demidowich, Lauren B. Shomaker, Amber B. Courville (+2 others)
2015 NeuroImage  
The interpersonal model of loss of control (LOC) eating proposes that socially distressing situations lead to anxious states that trigger excessive food consumption. Self-reports support these links, but the neurobiological underpinnings of these relationships remain unclear. We therefore examined brain regions associated with anxiety in relation to LOC eating and energy intake in the laboratory. Twenty-two overweight and obese (BMIz: 1.9±0.4) adolescent (15.8±1.6y) girls with LOC eating (LOC+,
more » ... n=10) and without LOC eating (LOC−, n=12) underwent functional magnetic resonance imaging (fMRI) during a simulated peer interaction chatroom paradigm. Immediately after the fMRI scan, girls consumed lunch ad libitum from a 10,934-kcal laboratory buffet meal with the instruction to "let yourself go and eat as much as you want." Pre-specified hypotheses regarding activation of five regions of interest were tested. Analysis of fMRI data revealed a significant group by peer feedback interaction in the Correspondence to:
doi:10.1016/j.neuroimage.2014.12.054 pmid:25550068 pmcid:PMC4323624 fatcat:5cwg34f6a5h7hnfuiqrv5t6mga