Rapidly-Dissolvable Microneedle Patches Via a Highly Scalable and Reproducible Soft Lithography Approach

Robert D. Geil, John H. Fain, Ashish A. Pandya, Christine F. Archuleta, Lissett R. Bickford, Yapei Wang, Adrian T. O'Neill, Katherine A. Moga, Stuart S. Dunn, Joseph M. Desimone
Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible microneedles (made by using a soft lithography process known as PRINT) showed efficacy in piercing both murine and human skin samples and
more » ... samples and delivering a fluorescent drug surrogate to the tissue.
doi:10.17615/pfpc-m970 fatcat:thqkqg34zvc5lkhaq6lhm22fnu