Meme kanseri hücre hatlarında propranolol ve paklitakselin anjiyogenez üzerine etkisi

Fatma Şimşek, Sevinç İnan, Sevda Müftüoğlu, Kemal Özbilgin, Seda Vatansever, İbrahim Tuğlu
2019 Cukurova Medical Journal  
Öz Purpose: The aim of this study was to investigate the effect of propranolol (PR), which is used in infantile hemangiomas, and paclitaxel (PX), which is widely used as an chemotherapeutic agent, on cancer cells. Materials and Methods: That the cells counted with trypan blue the doubling time were determined. Also with MTT assay were analyzed the cytotoxic effect and IC50 value of drugs. In the breast cancer cell lines which are differents with regard to invasion (MDA-MB-231 and MCF-7 )
more » ... and MCF-7 ) anti-VEGF, anti-eNOS, anti-iNOS and anti-ERK1/2 primer antibodies investigated by using immunohistochemical methods. To evaluation of immunoreactivity was used the H-scoring system.
doi:10.17826/cumj.418346 fatcat:f7srwae3mrcitil52k5ghork5y