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Gnetum africanum is native to West and Central Africa. The Phenotypic diversity within the Gnetacea is significant in the Niger Delta region of Nigeria where the leaf is consumed as vegetable. The ethanolic extract of the leaf was Soxhlet extracted. Three graded doses were estimated by acute toxicity tests. 20 female rats weighing between 120-150 grams were divided into 4 groups. Group 1-3 received (10, 200, and 700 mg/kg/d) of extract, group 4 received Normal Saline as control, respectively,doi:10.9790/3013-25303133 fatcat:ehnfauzexrfg3j527vfe2bnfwq