Prediction of short-term newborn infectious morbidity based on maternal characteristics in patients with PROM and Ureaplasma species infection

Mateusz Mikołajczyk, Przemysław Wirstlein, Magdalena Wróbel, Jan Mazela, Karolina Chojnacka, Jana Skrzypczak
2015 Ginekologia Polska  
Predykcja infekcji u noworodków w oparciu o analizę wyników danych pacjentek z przedwczesnym pęknięciem błon płodowych i infekcją Ureaplasma 0DWHXV] Abstract Objectives: Preterm premature rupture of membranes (PPROM) complicates about 5% of pregnancies. Ureaplasma species is the most common pathogen found in the amniotic fluid in pregnancieneonatal outcome. The aim of the following study was to evaluate the impact of colonization with the Ureaplasma spp. on pregnant women with PPROM,
more » ... h PPROM, coinfection with different microorganisms, and antimicrobial treatment on neonatal outcome. Material and methods: The study included 30 women with PPROM hospitalized in Division of Reproduction in s complicated by PPROM. It is speculated that it requires a coinfection to produce unfavorable Poznan' s K. Marcinkowski University of Medical Sciences. Swabs from cervical canal were obtained for the identification of bacterial and ureaplasmatic infections by culture and PCR. Results: The presence of any infection during the pregnancy after PPROM was confirmed in 22 patients (Ureaplasma spp. in 12 patients, coinfection in 10 women). The cure rate for Ureaplasma species and other infections was 17% (2/12 patients) and 23% (5/22 patients), respectively. There was no correlation between Ureaplasma species infection, coinfection, and cure status with the infection in the newborn. The PPROM to delivery duration also did not affect the newborn infection status. A negative relationship with leukocyte level was detected in patient with newborn infection. Conclusions: The presence of colonization with Ureaplasma species is not attributable to neonatal short-term morbidity. The evaluation of maternal biochemical and microbiological data, regardless of the duration of the pregnancy after PPROM or the cure status, does not add any insight into the newborn infection status.
doi:10.17772/gp/57857 fatcat:h6uarczelbfehbzcek2sfhvvjm