Porous Scaffold Coated with Poly(lactic acid-co-ε-caprolactone) on Chitosan Surface
키토산 표면에 PLCL을 코팅한 다공성 지지체

Ji Hye Kim, Ji Hye Kim
2017 Porrime  
Chitosan, a natural polymer, has excellent water content and is widely used in drug delivery systems, food additives and coatings in various fields. However, it has a disadvantage in that it has poor mechanical properties and dissolves in an aqueous solution containing an acid. In this study, poly(lactic acid-co-ε-caprolactone) (PLCL) was coated on chitosan scaffold surface in order to increase the mechanical strength of chitosan. Surface structure of pure chitosan scaffold and chitosan/PLCL
more » ... ffold were analyzed with swelling test, water contact angle and drug delivery system (DDS). As a result, the surface pores of the chitosan/PLCL were formed with microcapsules of 10 to 100 µm, and the contact angle of the surface was 8 o , showing hydrophilic properties. As a result, the chitosan/PLCL scaffold showed 1.1 times better DDS than the pure chitosan scaffold, and the mechanical strength and cell survival rate were 2 times higher. The results showed that the physical strength was increased by coating PLCL on the surface of pure chitosan, and the microporosity was formed by the salt leaching method to improve the water content and contact angle to improve the drug release function. It is considered that the present invention can be applied to various medical fields based on the result that biocompatibility is also increased by microporosity formation.
doi:10.7317/pk.2017.41.4.735 fatcat:cmb5xm7mpbei3bojvbkg5da6d4