Extracellular signal-Regulated Kinases 1/2 and their role in cardiac diseases

2015 Science Proceedings  
Mitogen-activated protein (MAP) kinases are members of a well-studied family of serine/threonine protein kinases involved in signal transduction pathways, which control multiple cellular processes. The extracellular signal-regulated kinase (ERK1/2) cascade is a MAP kinase pathway that transmits signals from the cell surface to substrates either in the nucleus or in the cytoplasm. The transmission of the signal through the ERK1/2 cascade is mediated by serial phosphorylations and activations of
more » ... rotein kinases. Abnormal regulation of the ERK1/2 signals has been linked to diseases and recent work clearly implicated ERK1/2 signaling in the development of cardiac pathologies. Understanding the underlying mechanism and the consequences of the aberrant modulation of ERK1/2 cascade will lead to the development of pharmacologic inhibitors for the treatment of these cardiac disorders.
doi:10.14800/sp.457 fatcat:if6e2mxvcfcidpapzpkygl2zk4