The aim of the study was to evaluate the effect of zinc hyaluronate on neuropathic and neuroischemic diabetic foot ulcers in a controlled, randomized, open-label trial. Fifty-nine patients with 71 ulcers (44 neuropathic and 27 neuroischemic) were treated with standard methods. In 35 patients (43 ulcers), zinc hyaluronate (Hyaluricht, Gedeon Richter, Hungary) was added locally. The rest of 24 patients (28 ulcers) remained on conventional therapy. Ulcer healing was recorded in 93% of the

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... t group and 82% of the control group, the mean time to healing being 74±31 and 92±25 days, respectively, yielding a significant difference between the two groups (p=0.008). For neuropathic ulcers, the rate of healing was 100% in the Hyaluricht group and 94% in the control group. Healing was achieved in 13/16 and 7/11 neuroischemic ulcers in the Hyaluricht and control group, respectively. These data show that Hyaluricht has a favorable effect on diabetic foot ulcers by promoting ulcer healing. The results obtained in this trial suggest that zinc hyaluronate could be included as an important element in the complex therapeutic approach for diabetic foot ulcers. 93