A new equivalence based metric for predictive check to qualify mixed-effects models

Pravin R. Jadhav, Jogarao V. S. Gobburu
2005 AAPS Journal  
The main objective of any modeling exercise is to provide a rationale for effective decision making during drug development. The aim of the current simulation experiment was to evaluate the properties of predictive check as a covariate model qualification technique and, more importantly, to introduce and evaluate alternative criteria to qualify models.
doi:10.1208/aapsj070353 pmid:16353930 pmcid:PMC2751255 fatcat:jr73xzb3ubdwnm44nbvlab2wg4