Rapid structural analysis of minute quantities of organic solids by exhausting 1H polarization in solid-state NMR spectroscopy at fast MAS [post]

Zhiwei Yan, Rongchun Zhang
2021 unpublished
Solid-state nuclear magnetic resonance (NMR) is a powerful and indispensable tool for structural and dynamic studies of various challenging systems. Nevertheless, it often suffers from significant limitations due to the inherent low signal sensitivity when low- nuclei are involved. Herein, we report an efficient solid-state NMR approach for rapid and efficient structural analysis of minute amounts of organic solids. By encoding staggered chemical shift evolution in the indirect dimension and
more » ... aggered acquisition in 1H dimension, a proton-detected homonuclear 1H/1H and heteronuclear 13C/1H chemical shift correlation (HETCOR) spectrum can be obtained simultaneously in a single experiment at fast magic-angle-spinning (MAS) conditions with barely increasing experimental time, compared to conventional proton-detected HETCOR experiment. We establish that abundant 1H polarization can be efficiently manipulated and fully utilized in proton-detected solid-state NMR spectroscopy for extraction of more critical structural information and thus reduction of total experimental time.
doi:10.33774/chemrxiv-2021-66zd8 fatcat:wbmhv6tqlvh5dhtawn23qkyff4